March 2002

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Posted Thursday, March 28, 2002 by Rick
Cardiac findings of reactive arthritis: an observational echocardiographic study
Timo Hannu1, , Markku S. Nieminen2, Heikki Swan2 and Marjatta Leirisalo-Repo1

(1) Department of Medicine, Division of Rheumatology, Helsinki University Central Hospital, P.O. Box 263, 00029 Huch, Finland
(2) Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, P.O. Box 340, 00029 Huch, Finland

Abstract. The aim of this study was to assess echocardiographically the occurrence of cardiac abnormalities in patients with acute reactive arthritis (ReA). Eighteen consecutive adult patients with acute ReA were studied by the use of two-dimensionally guided M-mode and Doppler echocardiography. Aortic or mitral regurgitation were both detected in one of the patients. Mild to moderate left ventricular dilatation was observed in five patients, in four of whom the duration of acute ReA was over 6 months. In four patients, the ratio of peak early and peak late transmitral filling velocities was decreased. No patient had echocardiographic signs of myocarditis or pericardial effusion. In conclusion, no major structural cardiac alterations were detected. Mild valvular disease or mild to moderate left ventricular dilatation was observed in a quarter of the patients. Echocardiographic evaluation may be warranted if the acute ReA persists or has a prolonged course but is not recommended for routine use.

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Potentially Dangerous Oral Spots and Sores Need More Attention
SUFFERN, NY -- March 28, 2002 -- A new study found that nearly one in ten people in an assumed low-risk group had small oral lesions that need to be tested for abnormalities that could be oral cancer.

Based on these findings, general dentists should be encouraged to examine their patients, even those assumed at "low risk" for spots and sores that could be early signs of this devastating disease.

As reported in the March 2002 edition of the Journal of the American Dental Association, 930 dentists and dental hygienists took advantage of a screening program at the 1999 and 2000 annual sessions of the American Dental Association during which they received routine health screening tests including oral, head and neck cancer examinations.

Eighty-nine individuals -- nearly 10 percent -- with 93 oral spots and sores, also referred to as epithelial lesions, were identified and evaluated by OralCDx, an oral brush biopsy with a computer-assisted method of analysis. Seven of the 93 oral lesions, all harmless-appearing in their clinical presentation, were determined to be abnormal by the OralCDx test. Of these, three subsequently proved pre-cancerous by scalpel biopsy and histology.

"This study confirms the data from other screening studies that have demonstrated that oral lesions are not rare, but are, in fact, extremely common, even in low risk individuals," said study author David C. Christian, DDS. "Given that 10 percent of screened dentists and dental hygienists, an assumed low-risk group, have an epithelial oral lesion, it is evident that general dentists routinely encounter many oral lesions in their patients which should be further tested for abnormalities that could be precursors to oral cancer.

The brush biopsy affords the dentist the opportunity to evaluate these lesions and, like the Pap smear and mammogram, can aid in the identification of pre-cancers and potentially curable cancers," he continued.

Oral cancer affects some 30,000 Americans each year, including more than 20,000 men, and claims the lives of nearly 8,000 people, according to the American Cancer Society. Although tobacco users and those who consume large amounts of alcohol are at higher risk for developing oral cancer, more than 25 percent of oral cancer victims fall outside of these categories.

In its earliest, most treatable stages, oral cancer generally causes no pain or discomfort and may be difficult to diagnose visually. Pre-cancerous and cancerous spots or sores are virtually indistinguishable from benign spots or sores that commonly are seen in the mouth. As a result, these can progress to a more advanced, malignant stage before they are properly identified. Therefore, an oral cancer examination and testing is necessary in order to detect possible disease at its earliest possible stage.

SOURCE: CDx Laboratories





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Posted Wednesday, March 27, 2002 by Rick
Merck Pulls Arcoxia Filing, to Resubmit - new 76%
... and will supply new clinical data to seek permission for Arcoxia's use to treat ankylosing spondylitis, a chronic inflammation of the spine affecting 350,...
Found by: Yahoo! News
http://story.news.yahoo.com/news?tmpl=story&u=/nm/20020315/bs_nm/health_merck_dc_3

Enbrel rival builds steam as FDA OKs claim that drug improves function - new 70% Enbrel isn't the only biotech drug that works for rheumatoid arthritis, and Immunex's top competitor is gaining on it. Yesterday, Johnson & Johnson said the Food and Drug Administration...
Found by: Seattle Times
http://archives.seattletimes.nwsource.com/cgi-bin/texis.cgi/web/vortex/display?slug=remicade01&date=20020301

FDA Approves Production Of Initial Lots At Nabi Biopharmaceuticals Boca Raton Facility - new 72%
... focused on the development and commercialization of drugs that prevent and treat infectious and autoimmune diseases....
Found by: Yahoo! News
http://biz.yahoo.com/prnews/020327/flw005_1.html

Biogen and MIT Establish Toxicology Fellowship Program - new 66%
... research and development activities are focused on novel products to treat inflammatory and autoimmune diseases, neurological diseases, cancer, fibrosis and congestive heart failure....
Found by: Yahoo! News
http://biz.yahoo.com/cnw/020326/ma_biogen_mit_progrm_1.html

Corgenix Signs Distribution Agreement With RhiGene; Products Significantly Enhance Autoimmune Diagnostic Offering - new 41%
... agreement will grant Corgenix exclusive rights to distribute RhiGene's complete diagnostic line of autoimmune testing products in North and South America....
Found by: Yahoo! News
http://biz.yahoo.com/prnews/020321/lath002_1.html

Herpes Vaccine From CEL-SCI Corporation Demonstrated to Be Protective in New Animal Model - new 40%
... which antigenic epitope sequences have been identified, such as infectious diseases, cancer, autoimmune diseases, allergic asthma and allergy, are potential candidates for this technology....
Found by: Yahoo! News
http://biz.yahoo.com/prnews/020325/dcm013_1.html

Chronic fatigue associated with additional health problems - new 80% Health Having chronic fatigue syndrome appears to be associated with an increased risk of developing other physical health problems suggest the results of a small study of identical and fraternal twins. ”Physicians should assess CFS patients for the presence of additional clinical conditions ” said lead author Leslie A. Aaron PhD MPH of the Department of Medicine at University of Washington.
Found by: RocketNews
http://www.pain.com/news/news.cfm?news__nid=1024

Prozac May Offer Short-Term Fibromyalgia Relief - new 76%
...Fibromyalgia is a chronic condition, often accompanied by depression and fatigue, in which a person feels pain in the...... including SSRIs, are effective in treating patients who have such
symptom syndromes as fibromyalgia, but many questions remain as to why, how much,...
Found by: Yahoo! News
http://story.news.yahoo.com/news?tmpl=story&u=/nm/20020321/hl_nm/prozac_fibromyalgia_1

Finally, Science Weighs In
Many people swear by nontraditional therapies such as acupuncture and herbs. To determine the value of these alternatives to consumers, government researchers are testing unconventional medicine. Found by: Los Angeles Times
http://www.latimes.com/features/health/la-031802straus.story

New Hope to Prevent Blindness in Children - new 72%
...This investigation demonstrates that the same medication can successfully treat conjunctivitis (``red eye'') as well as standard antibiotics or better if the infection is caused by bacteria...
Found by: Yahoo! News
http://biz.yahoo.com/prnews/020318/sfm149_1.html

Pink Eyes Behind Ivy Walls - new 68%
... League schools have been swamped with cases of the benign infection known as pink eye, or conjunctivitis. More than 500 students at Dartmouth's campus in Hanover, N.H.,...
Found by: Yahoo! News
http://story.news.yahoo.com/news?tmpl=story&u=/hsn/20020316/hl_hsn/pink_eyes_behind_ivy_walls

Remicade(R) (Infliximab) Granted Priority Review by FDA for Long-Term Treatment of Crohn's Disease - new 72%
Centocor, Inc. today announced that REMICADE(R) has been designated for priority review by the U.S. Food and Drug Administration as a monotherapy for inducing and maintaining clinical remission in patients with moderately to severely active Crohn's disease, a gastrointestinal disorder that affects more than a half-million Americans.
Found by: Yahoo! News
http://biz.yahoo.com/prnews/020321/nyth126_1.html

IVAX to Proceed to Phase II Study of Its Soft Corticosteroid BNP-166 for Crohn's Disease - new 65%
IVAX Corporation(LSE:IVX.L) announced today it has successfully completed a Phase Ib study for Crohn's disease, an inflammatory disease of the small bowel, of an oral form of its "soft
corticosteroid", BNP-166.
Found by: Yahoo! News
http://biz.yahoo.com/bw/020321/212007_1.html

Intravenous Use of Arthritis Drug OK'd - new 46%
...Remicade has also been FDA-approved for the treatment of Crohn's disease, a gastrointestinal ailment. And while the drug continues to be effective in combatting...
Found by: Yahoo! News
http://story.news.yahoo.com/news?tmpl=story&u=/hsn/20020315/hl_hsn/intravenous_use_of_arthritis_drug_ok_d

InKine Announces FDA Approval of "New Formulation" of Visicol - new 44% ... thrombocytopenic purpura and Colirest(TM), in pivotal clinical trials for the treatment of Crohn's disease and completed Phase II trials for the treatment of ulcerative colitis....
Found by: Yahoo! News
http://biz.yahoo.com/bw/020314/142121_1.html

Catheters Ease Complications of Crohn's Disease - new 30%
SATURDAY, March 2 (HealthScoutNews) -- Threading a catheter through the skin to drain pelvic or abdominal abscesses in people with Crohn's disease is highly effective, and can delay or avoid surgery.
Found by: Yahoo! News
http://story.news.yahoo.com/news?tmpl=story&u=/hsn/20020303/hl_hsn/catheters_ease_complications_of_crohn_s_disease

DOR BioPharma Receives First European Orphan Drug Designation - new 14% ... gastrointestinal disorders including a multicenter phase II trial in the United States for Crohn's disease that affects an estimated 500,000 person according to the Crohn's and Colitis
Foundation....
Found by: Yahoo! News
http://biz.yahoo.com/bw/020228/282178_1.html

FDA Approves REMICADE(R) (Infliximab) With Methotrexate As First Drug To Improve Physical Function In Rheumatoid Arthritis - new 16%
... factor alpha (TNF-a) therapies and the only biologic drug indicated for the treatment of RA and Crohn's disease, a potentially devastating gastrointestinal disorder....
Found by: Yahoo! News
http://biz.yahoo.com/iw/020228/038735.html

Crohn’s & Colitis Foundation of America Searching for ’Local Heroes’ - new 74%
... between the ages of 7 and 17 who have shown courage and determination while living with Crohn’s disease or ulcerative colitis (collectively known as inflammatory bowel disease or IBD).......These diseases can be both physically and emotionally devastating, especially to kids....
Found by: Yahoo! News
http://biz.yahoo.com/bw/020325/250295_1.html

Nobex Announces Collaboration With Pharmacia For Oral Delivery of Protein Drug - new 72% ...A third product, Apaza(TM) for inflammatory bowel disease, is expected to enter clinical study in 2002....
Found by: Yahoo! News
http://biz.yahoo.com/prnews/020325/nym022_1.html

Feds scrutinize Oregon's marijuana law - new 74%
PORTLAND For unknown reasons the General Accounting Office the investigative arm of Congress is looking into the medical marijuana programs in Oregon and three other states. It's a little baffling and it's an uncomfortable kind of bafflement said Mary Leverette acting manager of Oregon's 3-year-old program that allows sick people to grow and smoke marijuana with a doctor's permission.
Found by: RocketNews
http://www.registerguard.com/news/20020324/3c.cr.medicalpot.0324.html

Nations' drug policies on collision course - new 63%
Canada's marijuana policies may put it on a collision course with the United States. The two countries share the world's longest inprotected border and annual trade tops 400 million but they have clashed before over such issues as Cuba eliminating land mines and the death penalty.
Add marijuana to the list.
Found by: RocketNews
http://www.pressdemocrat.com/local/news/24pot_a15empirea.html

Marijuana blamed for brain problems - new 57%
An estimated 7 million people in the United States use marijuana weekly. Marijuana blamed for brain problems Heavy users suffer memory loss, inattentiveness, study finds March 5 — Heavy, chronic marijuana users suffer memory loss and attention Found by: MSNBC
http://www.msnbc.com/news/719638.asp

Medical advisers back cannabis reform - new 39%
BBC - Mar 14 2002
Found by: Yahoo! News Full Coverage
http://news.bbc.co.uk/hi/english/uk/newsid_1872000/1872524.stm

Immunex arthritis treatment in short supply - new 70%
BLOOMBERG NEWS Immunex Corp. is telling doctors and pharmacists that some patients taking the rheumatoid arthritis treatment Enbrel may not be able to get the drug for a few days to a few weeks. The company sent letters Thursday to physicians and pharmacists notifying them of the delays Immunex spokeswoman Robin Shapiro said.
Found by: RocketNews
http://seattlep-i.nwsource.com/business/63551_immunex23.shtml

New Substance Identifies Disease-Causing Agent - new 76%
... could offers clues to aging and other diseases linked to oxygen radicals. "We produce reactive oxygen radicals all the time, [including] as byproducts of respiration and any time we have......-- cancer, arthritis, heart disease, Alzheimer's and other sorts of neurological degenerative disease-...
Found by: Yahoo! News
http://story.news.yahoo.com/news?tmpl=story&u=/hsn/20020323/hl_hsn/new_substance_identifies_disease_causing_agent

Ibuprofen blocks aspirin’s ability to protect against heart attacks - new 73%
Pennsylvania Medical Center Common arthritis drugs can stop aspirin from thinning the blood Philadelphia PA – The ibuprofen that you take to ease arthritis pain can counteract the aspirin that you take to protect your heart according to researchers at the University of Pennsylvania School of Medicine. The researchers studied how aspirin taken to prevent second heart attacks interacts with nonsteroidal anti-inflammatory drugs NSAIDs a group of drugs that includes ibuprofen commonly taken to treat rheumatoid arthritis.
Found by: RocketNews
http://www.pain.com/news/news.cfm?news__nid=1027

Protein Design Psoriasis Drug Fails Tests - new 76%
... and currently there are trials under way in asthma, multiple sclerosis, type I diabetes and uveitis," the company said....
Found by: Yahoo! News
http://story.news.yahoo.com/news?tmpl=story&u=/nm/20020320/sc_nm/health_proteindesign_dc_2





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Posted Tuesday, March 26, 2002 by Rick
By Janice Billingsley
HealthScoutNews Reporter

FRIDAY, March 1 (HealthScoutNews)

http://www.healthscout.com/template.asp?page=newsdetail&ap=409&id=505909


Good reference for rating pain as well as suggestions and
observations about living with pain.
Ray

http://www.acs.ohio-state.edu/units/osuhosp/patedu/homedocs.pdf/medicatn.pdf/nondrug.pdf/paincontrol.pdf





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Posted Wednesday, March 20, 2002 by Rick
UWGB basketball players toughest opponent is Crohns disease - new 66%
Elizabeth Dudley never rests. She relentlessly pressures opposing point guards as they bring the ball up the floor against the University of Wisconsin-Green Bay womens basketball team. Her
cat-like quickness is a tremendous asset, almost as valuable as her unending hustle and determination.
Found by: FAST Search (alltheweb.com)
http://www.greenbaypressgazette.com/sports/archive/sports_2850777.shtml

Making sense of antisense - Isis of Carlsbad is leader in key biotech field - new 53%
Making sense of antisense - Isis of Carlsbad is leader in key biotech field March 17 - A single cell contains molecular gadgetry far more complicated than any brilliant feat of human engineering, such as the space shuttle or even Microsoft's Windows
Found by: MSNBC
http://www.msnbc.com/local/tem/m160546.asp

Major Genetic Diseases - new 53%
Abstract: Major genetic diseases. The 23 pairs of chromosomes are identified by number, according to size. Chromosome 1 is the largest, chromosome 22 the smallest. The other pair of chromosomes are the sex chromosomes, designated X and Y. Women have two of the large X
chromosomes and men have one large X and (8,713 bytes)
Found by: Pittsburgh Post-Gazette
http://www.post-gazette.com/genome/diseases.asp

Neil Sedaka to Perform and Monty Hall to M.C. 26th Annual Crohn's And Colitis Foundation Testimonial Dinner and Live Auction - new 76%
... voluntary health organization dedicated to improving the quality of life for persons with Crohn's disease or ulcerative colitis.......Known collectively as inflammatory bowel diseases
(IBD), these chronic digestive disorders affect up to two million Americans....
Found by: Yahoo! News
http://biz.yahoo.com/prnews/020314/lath075_1.html

HHS Urges Colorectal Cancer Screening To Save Lives - new 74%
... obesity, alcohol consumption, tobacco use, and a condition known as inflammatory bowel disease....
Found by: Yahoo! News
http://story.news.yahoo.com/news?tmpl=story&u=/020313/180/193i9.html

SkyePharma to Acquire 100% of RTP Pharma Inc; Signs Agreement to Fund New Product Development - HFA-Formoterol and RTP's Propofol - new 72% ... an intravenous formulation of the antibiotic oxytetracycline and oral budesonide, to treat inflammatory bowel disease....
Found by: Yahoo! News
http://biz.yahoo.com/prnews/020313/nyw047_1.html

Cytokine suppressive anti-inflammatory drug binding protein - new 66% PharmCast - Mar 14 2002 4:26AM GMT
Found by: Moreover
http://www.pharmcast.com/Patents/Yr2002/Feb2002/022602/6350856_Cytokine022602.htm

Medical Marijuana Bill Passed By Vermont House - new 69%
Medical Marijuana Bill Passed By Vermont House MONTPELIER, Vt., 8:19 p.m. EST March 15, 2002 - The Vermont House of Representatives approved a bill Friday that would legalize marijuana for medicinal purposes. The measure passed 82-59. If the Found by: MSNBC
http://www.msnbc.com/local/wptz/a1121460.asp

Ruling puts limit on growing medical pot - new 67%
Spokesman-Review.com reg - Mar 18 2002 8:56PM GMT
Found by: Moreover
http://www.spokesmanreview.com/news-story.asp?date=031802&ID=s1117915&cat=section.regional

Living with psoriasis - new 70%
Q. What causes psoriasis? Are there any new treatments for this condition?
Found by: The Boston Globe
http://www.boston.com/dailyglobe2/076/north/Living_with_psoriasis+.shtml

Arthritis sidelines Johns - new 79%
SILVERCHAIR frontman Daniel Johns is suffering from a rare strain of arthritis. Doctors have put the 22-year-old millionaire on antibiotics to combat a virus which provoked the reactive arthritis. When you say arthritis people assume it's what grandma's got and it's not silverchair manager John Watson said yesterday.
Found by: RocketNews
http://www.thesundaymail.news.com.au/common/story_page/0,5936,3976057^10431,00.html

Star's arthritis battle reactive arthritis - new 76%
Sydney Morning Herald - Mar 17 2002
Found by: Yahoo! News Full Coverage
http://www.smh.com.au/news/0203/18/entertainment/entertain3.html

Arthritis sidelines silverchair star - new 75%
SILVERCHAIR frontman Daniel Johns is suffering from a rare strain of arthritis. Doctors have put the 22-year-old millionaire on antibiotics to combat a virus which provoked the reactive arthritis. When you say arthritis people assume it's what grandma's got and it's not silverchair manager John Watson said yesterday.
Found by: RocketNews
http://www.thecouriermail.news.com.au/common/story_page/0,5936,3976057^7484,00.html

Repeated Infliximab Safe, Effective in Spondyloarthropathy - new 76% Medscape reg - Mar 20 2002 3:52AM GMT
Found by: Moreover
http://www.medscape.com/viewarticle/430137





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Posted Thursday, March 14, 2002 by Rick
[1] Arizona Research and Education Ltd, Phoenix, Arizona, USA [*]Correspondence and offprints: Sanford H. Roth, Arizona Research and Education Ltd, 3330 N. 2nd Street Suite 601, Phoenix, AZ 85012, USA.

Abstract:

Arthritis, rheumatic diseases, spinal and peripheral joint disorders share in common a legacy of chronic pain. At the turn of the millennium, nonsteroidal anti-inflammatories (NSAIDs) had replaced aspirin as the agents most commonly used to deal with rheumatic symptoms, including pain. Paracetamol (acetaminophen) was the most common alternative analgesic for minor pain. Opioids were most commonly used on an ad-lib basis, usually for ‘breakthrough’ pain. However, neurobiological research has confirmed the basis for 24-hour around-the-clock complete suppression of chronic nonmalignant pain. This avoids the ‘wind up’ that leads to intractable pain progression. Proper monitoring, in the absence of the end organ toxicity seen with NSAIDs, allows a change in direction to opioids for arthritis for more severe pain. This requires understanding the responsibilities of maintaining opioids, in properly selected patients, based upon host response and informed consent. Under such circumstances, evidence-based trials support the use of stronger opioids in recalcitrant chronic pain of arthritis. Thus, we endeavour to better fulfill our Oath of Hippocrates: ‘to relieve pain and suffering’.

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Gastroprotective Therapy and Risk of Gastrointestinal Ulcers: Risk Reduction by COX-2 Therapy

FREDERICK WOLFE, JANICE ANDERSON, THOMAS A. BURKE, LESTER M. ARGUELLES, and DAN PETTITT

ABSTRACT.

Objective. Proton pump inhibitors (PPI) and misoprostol decrease the risk of development of nonsteroidal antiinflammatory drug induced gastric ulcers and aid healing of upper gastrointestinal (GI) ulcers. H2 receptor antagonists (H2RA) are less effective for this task, but are widely used by patients and physicians for the treatment of GI symptoms and duodenal ulcers. Sucralfate is a weaker agent that is sometimes used for prophylaxis or treatment of upper GI ulcers. We investigated the effect of GI drugs and selective and nonselective NSAID on the incidence of GI ulcer development in a cohort of patients immediately after the release of celecoxib and rofecoxib to investigate the effect of confounding by indication when effective GI agents and cyclooxygenase 2 (COX-2)-specific inhibitors are prescribed to a high risk population.

Methods. During a 6 month period of observation 8547 NSAID users were evaluated by mailed questionnaire concerning NSAID drug use and ulcer development. In the first half of 1999, patients took 12,177 separate NSAID courses. GI therapy that followed the development of upper GI ulcers was excluded from analysis. Ulcer reports were confirmed by followup validation.

Results. GI drugs were used concomitantly in this population by 42% of patients using an NSAID. GI drugs were associated with an increased risk of ulcer. But this risk was confined to PPI (OR 4.1, 95% CI 2.95, 5.69), and not to other GI drugs. Overall, patients using nonselective NSAID compared to those taking COX-2-specific inhibitors had an increased risk of upper GI ulcers (OR 2.12, 95% CI 1.43, 3.34). Patients taking nonselective NSAID plus PPI were also at increased risk for upper GI ulcers compared to those taking nonselective NSAID alone (OR 5.09, 95% CI 3.88, 6.67). Similarly, the risk of upper GI ulcers was increased in the nonselective NSAID plus PPI group (OR 3.83, 95% CI 2.32, 6.31) compared to the COX-2 plus PPI group.

Conclusion. PPI use, but not other GI drug use, is a marker for increased susceptibility to ulcers among NSAID users. This risk of upper GI ulcers is increased in PPI users regardless of which NSAID is used (nonselective or COX-2-specific inhibitor). Although COX-2 use is associated with greater risk factors for upper GI ulcers due to channeling bias, COX-2 users have significantly fewer ulcers than equivalent nonselective NSAID users regardless of concomitant PPI utilization. (J Rheumatol 2002;29:467-73)

------------------------------------------------------

03/11/2002
By Anne MacLennan



Pre- and postmenopausal women with ankylosing spondylitis (AS) have reduced hip bone mineral density. As well, bone turnover in these patients is characterised by low serum osteocalcin and bone-specific alkaline phosphatase.

These are the findings of a study of bone mineral density (BMD), calcaneal ultrasound and bone turnover markers in women with this condition. Participants in the study were 50 pre- and 16 postmenopausal women with AS; 132 women of similar age served as controls.

The objective of these researchers was two-fold: 1) to assess BMD using dual energy x-ray absorptiometry (DEXA) and calcaneal quantitative ultrasound (QUS) in women with ankylosing spondylitis (AS), and 2) to determine if there are any relationships between bone turnover markers and disease activity or severity.

Researchers assessed clinical and radiological status by the Bath AS Disease Activity Index (BASDAI), Bath AS Functional Index (BASFI), Bath AS Metrology Index (BASMI) and Bath AS Radiology Index (BASRI). BMD of the hip and spine was measured by DEXA, and QUS was measured at the heel.

Serum osteocalcin (OC), bone-specific alkaline phosphatase (BALP), urinary D-pyridinoline crosslinks (D-PYR), and C-reactive protein (CRP) were assayed.

The 66 women with AS compared with control patients had reduced BMD at the hip. For pre- and postmenopausal women, mean t scores were -1.1 and -2.0 respectively, and z scores were -0.4 and -0.37. Four of the women (6 percent) had osteoporosis, and 34 (52 percent) had osteopenia by the WHO definitions.

In further analysis (multiple regression), the authors found femoral neck BMD to be significantly affected by age, body mass index, and the sacroiliac radiographic score.

There were no significant correlations of BMD with disease duration or disease activity. QUS measures did not correlate with DEXA measures of BMD.

Women with AS had significantly lower markers of bone formation, OC and BALP, and a trend to higher D-PYR than controls. Serum OC levels correlated negatively with femoral neck BMD, whereas D-PYR correlated with CRP levels.





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Posted Wednesday, March 13, 2002 by Rick
Infliximab May Offer Hope for Patients Living With Spondyloarthropathy - new 70%
PR Newswire via Yahoo - Mar 11 2002 3:10PM GMT
Found by: Moreover
http://biz.yahoo.com/prnews/020311/nym015_1.html

Biogen Schedules Conference Call for Media Regarding FDA Ruling - new 72%
... research and development activities are focused on novel products to treat inflammatory and autoimmune diseases, neurological diseases, cancer, fibrosis and congestive heart failure....
Found by: Yahoo! News
http://biz.yahoo.com/bw/020308/82063_1.html

Genzyme Molecular Oncology Reports 2001 Financial Results------ Progress Made in the Clinic and Through Partnerships - new 63%
... Oncology plans to work with partners in expanding its program into infectious disease and autoimmune disorders....
Found by: Yahoo! News
http://biz.yahoo.com/prnews/020307/neth003_1.html

Stanford's New Antigen Microarrays Open Window to Better Disease Screening - new 61%
...Until now, these disorders, called autoimmune diseases, have been difficult to diagnose and treat....
Found by: Yahoo! News
http://biz.yahoo.com/bw/020306/60394_1.html

Detecting eye problems in toddlers - new 70%
Detecting eye problems in toddlers What parents need to know to help their children see clearly By Brian Campolattaro THE TODAY SHOW March 9 — One in four school-age children has a vision problem that needs correcting. Young eyes develop Found by: MSNBC
http://www.msnbc.com/news/721329.asp

Interneuron Initiates Multiple-Dose Phase I Clinical Trial of Dersalazine for Inflammatory Bowel Disease - new 74%
...Future studies are planned to explore the utility of the drug in Crohn's disease....
Found by: Yahoo! News
http://biz.yahoo.com/bw/020307/72210_1.html

Brainerd woman strives to educate people about Crohn's disease - new 63% It's a chronic disease most people would rather not talk about. But a Brainerd woman is speaking out about her private battle with Crohn's disease in the hope that people will become educated about the disease, and help her raise funds to find a cure.
Found by: FAST Search (alltheweb.com)http://www.brainerddispatch.com/stories/031102/new_0311020018.shtml

For many, imaging technology is replacing exploratory surgery - new 74%
Inflammatory bowel disorders, such as Crohn's disease or Diverticulitis.
Found by: Minneapolis Star Tribune
http://www.startribune.com/stories/389/2000586.html

The cause of the inflammatory Crohns disease is unclear - new 72%
Philadelphia Inquirer - Mar 11 2002 9:24PM GMT
Found by: Moreover
http://www.philly.com/mld/philly/living/health/2835901.htm

Incara Granted Deligoparin Sodium as Generic Name for OP2000 - new 22% ...Deligoparin is being developed for the treatment of inflammatory bowel disease (IBD) by Incara Development, Ltd., which is jointly owned by Incara Pharmaceuticals......Comprised primarily of two diseases, ulcerative colitis (UC) and Crohn's disease (CD), IBD causes recurrent pain,...
Found by: Yahoo! News
http://biz.yahoo.com/prnews/020122/chtu005_1.html

Oxagen Subscribes to Celera's Genomic Databases - new 18%
..."Oxagen has built up extensive family collections covering a number of common human diseases....... sequence data plus the SNP database should greatly accelerate our progress in identifying disease genes and drug targets," said Trevor Nicholls, Ph.D., chief executive officer of Oxagen....... player in the study of complex disease genetics, conducting programs in cardiovascular disease, inflammatory disease and metabolic and endocrine disorders.......
cardiovascular disease (in partnership with AstraZeneca), inflammation (asthma, inflammatory bowel disease and psoriasis) and metabolic and endocrine disorders (osteoporosis,...
Found by: Yahoo! News
http://biz.yahoo.com/bw/020118/180048_1.html

Canadian doctors want marijuana decriminalized - new 71%
National Post Online - Mar 13 2002 1:02AM GMT
Found by: Moreover
http://www.nationalpost.com/news/national/story.html?f=/stories/20020312/313181.html

Zymogenetics sues Immunex for patent infringement - new 76%
... drug is approved by regulators to treat moderate to severe rheumatoid arthritis as well as psoriatic arthritis....
Found by: Yahoo! News
http://biz.yahoo.com/rf/020307/n0734952_2.html





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Posted Wednesday, March 6, 2002 by Rick
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God Bless.

Rick Hahn
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==========================================================

FDA Approves REMICADE(R) (Infliximab) With Methotrexate As First Drug To Improve Physical Function In Rheumatoid Arthritis - new 74%
... including ulcerative colitis, psoriasis and spondyloarthropathies, such as ankylosing spondylitis and psoriatic arthritis....
Found by: Yahoo! News
http://biz.yahoo.com/iw/020228/038735.html

Facts About REMICADE(R) (infliximab) - new 70%
...-- Spondyloarthropathies, such as ankylosing spondylitis and psoriatic arthritis -...
Found by: Yahoo! News
http://biz.yahoo.com/prnews/020228/nyth055_1.html

Enbrel effective in arthritis of spine - study - new 62%
iWon - Nov 12 2001 1:40AM GMT
Found by: Moreover
http://money.iwon.com/jsp/nw/nwdt_rt.jsp?section=news&news_id=reu-n06391082&feed=reu&date=20011111&cat=INDUSTRY

Study Links Children's Height to Diabetes Risk - new 59%
...Exactly what triggers this autoimmune reaction is unknown, although scientists think viral infections may play a role in some cases....
Found by: Yahoo! News
http://story.news.yahoo.com/news?tmpl=story&u=/nm/20020305/hl_nm/height_1

Interferons May Help Prevent Some Diabetes Cases - new 50%
... better understanding of what goes wrong in people with type 1 diabetes and other so-called autoimmune diseases that cause the immune system to turn against the body's own tissues,...
Found by: Yahoo! News
http://story.news.yahoo.com/news?tmpl=story&u=/nm/20020304/hl_nm/interferon_1

Dynavax, Johns Hopkins University and NIH-Sponsored Immune Tolerance Network Present New Positive Data From Phase II Study of Ragweed Immunotherapy Product (AIC) - new 48%
... accelerating the clinical use of tolerance therapeutics for islet and kidney transplantation, autoimmune disease, and allergy and asthma....
Found by: Yahoo! News
http://biz.yahoo.com/prnews/020302/sfsa001_1.html

Acupuncture May Aid Cancer Patients' Dry Mouth - new 44%
...--an autoimmune disease in which the immune system mistakenly attacks the salivary glands....
Found by: Yahoo! News
http://story.news.yahoo.com/news?tmpl=story&u=/nm/20020301/hl_nm/drymouth_1

Arthritis Foundation Statement on New FDA Approval For Remicade in Rheumatoid Arthritis - new 37%
...RA is an autoimmune disease in which the body's immune system attacks multiple joints leading to pain,...
Found by: Yahoo! News
http://biz.yahoo.com/prnews/020228/atth030_1.html

Catheters Ease Complications of Crohn's Disease - new 76%
SATURDAY, March 2 (HealthScoutNews) -- Threading a catheter through the skin to drain pelvic or abdominal abscesses in people with Crohn's disease is highly effective, and can delay or avoid surgery.
Found by: Yahoo! News
http://story.news.yahoo.com/news?tmpl=story&u=/hsn/20020303/hl_hsn/catheters_ease_complications_of_crohn_s_disease

DOR BioPharma Receives First European Orphan Drug Designation - new 59% ... gastrointestinal disorders including a multicenter phase II trial in the United States for Crohn's disease that affects an estimated 500,000 person according to the Crohn's and Colitis
Foundation....
Found by: Yahoo! News
http://biz.yahoo.com/bw/020228/282178_1.html

Special needs camps - new 76%
A camp for youth with Crohn's disease and ulcerative colitis.
Found by: Minneapolis Star Tribune
http://www.startribune.com/stories/1677/1901800.html

Inflammatory bowel disease
Health calendar - new 70%
For the week of March 3-9.
Found by: Seattle Times
http://archives.seattletimes.nwsource.com/cgi-bin/texis.cgi/web/vortex/display?slug=healthcal03&date=20020303

Gene May Help Suppress Colorectal Cancer - new 73%
NEW YORK (Reuters Health) - Genetically engineered mice are helping scientists understand how colorectal cancer develops in humans. Mice that lack just one particular gene are prone to develop benign tumors in the small intestine, and Found by: Lycos News
http://news.lycos.com/news/story.asp?section=Health&storyId=343424&topic=Inflammatory+Bowel+Disease

Study Links Marijuana to Brain Problems - new 77%
CHICAGO (Reuters) - Heavy, chronic marijuana users suffer memory loss and attention problems that can affect their work, learning and life, researchers reported on Tuesday. But in an indication of the controversy surrounding a drug said Found by: Lycos News
http://news.lycos.com/news/story.asp?section=Science&storyId=346589&topic=Medical+Marijuana

Therapeutic use allowed - new 32%
Therapeutic use allowed States that permit medical use of marijuana: Source: Americans for Medical Rights...
Found by: USA TODAY
http://www.usatoday.com/news/court/2001-03-28-marijuana-side.htm

Quick question results - new 20%
Quick question results Should marijuana be legalized for medical purposes? Total Votes: (Results updated every minute) Index of recent question results Found by: USA TODAY
http://www.usatoday.com/quick/news/qn1128a.htm

Virilitec Industries, Inc. Announces Plans to Develop Laser Photonics Device To Compete With PhotoMedex - new 70%
... a skin condition with symptoms ranging from slight irritation to severe conditions such as psoriatic arthritis, disability or even death....
Found by: Yahoo! News
http://biz.yahoo.com/prnews/020228/dath016_1.html

INTERACTIONS - new 76%
Nothing to Lose but My Pain Your Feb. 19 article ["Psoriatic Arthritis: A Growth Industry"] was intelligent, informative and likely quite helpful for ...
Found by: Washington Post
http://www.washingtonpost.com/wp-dyn/articles/A38728-2002Mar4.html